Detecting a Quasi-stable Imine Species on the Reaction Pathway of SHV-1 β-Lactamase and 6β-(Hydroxymethyl)penicillanic Acid Sulfone

[Image: see text] For the class A β-lactamase SHV-1, the kinetic and mechanistic properties of the clinically used inhibitor sulbactam are compared with the sulbactam analog substituted in its 6β position by a CH(2)OH group (6β-(hydroxymethyl)penicillanic acid). The 6β substitution improves both in...

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Veröffentlicht in:Biochemistry
Hauptverfasser: Che, Tao, Rodkey, Elizabeth A., Bethel, Christopher R., Shanmugam, Sivaprakash, Ding, Zhe, Pusztai-Carey, Marianne, Nottingham, Michael, Chai, Weirui, Buynak, John D., Bonomo, Robert A., van den Akker, Focco, Carey, Paul R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310624/
https://ncbi.nlm.nih.gov/pubmed/25536850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501197t
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