Rational design of a β-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 Å crystal structure of wt SHV-1 complex with a penam sulfone

β-Lactamases are one of the major causes of antibiotic resistance in Gram negative bacteria. The continuing evolution of β-lactamases that are capable of hydrolyzing our most potent β-lactams presents a vexing clinical problem, in particular since a number of them are resistant to inhibitors. The ef...

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Main Authors: Padayatti, Pius S., Sheri, Anjaneyulu, Totir, Monica A., Helfand, Marion S., Carey, Marianne P., Anderson, Vernon A., Carey, Paul R., Bethel, Christopher R., Bonomo, Robert A., Buynak, John D., van den Akker, Focco
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593906/
https://ncbi.nlm.nih.gov/pubmed/17017804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja063715w
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