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The importance of the trans-enamine intermediate as a β-lactamase inhibition strategy probed in inhibitor-resistant SHV β-lactamase variants
The ability of bacteria expressing inhibitor resistant (IR) β-lactamases is stimulating the development of novel inhibitors. SA2-13 was previously designed to enhance the stabilization of the deacylation refractory, trans-enamine inhibitory intermediate. To test whether this mode of inhibition can o...
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| Asıl Yazarlar: | , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3523351/ https://ncbi.nlm.nih.gov/pubmed/22438274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200006 |
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