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The importance of the trans-enamine intermediate as a β-lactamase inhibition strategy probed in inhibitor-resistant SHV β-lactamase variants

The ability of bacteria expressing inhibitor resistant (IR) β-lactamases is stimulating the development of novel inhibitors. SA2-13 was previously designed to enhance the stabilization of the deacylation refractory, trans-enamine inhibitory intermediate. To test whether this mode of inhibition can o...

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Detaylı Bibliyografya
Asıl Yazarlar: Ke, Wei, Rodkey, Elizabeth A., Sampson, Jared M., Skalweit, Marion J., Sheri, Anjaneyulu, Pagadala, Sundar Ram Reddy, Nottingham, Michael D., Buynak, John D., Bonomo, Robert A., van den Akker, Focco
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523351/
https://ncbi.nlm.nih.gov/pubmed/22438274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200006
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