Penam Sulfones and β-Lactamase Inhibition: SA2-13 and the Importance of the C2 Side Chain Length and Composition

β-Lactamases are the major reason β-lactam resistance is seen in Gram-negative bacteria. To combat this resistance mechanism, β-lactamase inhibitors are currently being developed. Presently, there are only three that are in clinical use (clavulanate, sulbactam and tazobactam). In order to address th...

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Bibliografische gegevens
Hoofdauteurs: Rodkey, Elizabeth A., Winkler, Marisa L., Bethel, Christopher R., Pagadala, Sundar Ram Reddy, Buynak, John D., Bonomo, Robert A., van den Akker, Focco
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894197/
https://ncbi.nlm.nih.gov/pubmed/24454944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085892
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