Crystal Structures of KPC-2 β-Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226

Class A carbapenemases are a major threat to the potency of carbapenem antibiotics. A widespread carbapenemase, KPC-2, is not easily inhibited by β-lactamase inhibitors (i.e., clavulanic acid, sulbactam, and tazobactam). To explore different mechanisms of inhibition of KPC-2, we determined the cryst...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Ke, Wei, Bethel, Christopher R., Papp-Wallace, Krisztina M., Pagadala, Sundar Ram Reddy, Nottingham, Micheal, Fernandez, Daniel, Buynak, John D., Bonomo, Robert A., van den Akker, Focco
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346646/
https://ncbi.nlm.nih.gov/pubmed/22330909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06099-11
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky