Crystal Structures of KPC-2 β-Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226

Class A carbapenemases are a major threat to the potency of carbapenem antibiotics. A widespread carbapenemase, KPC-2, is not easily inhibited by β-lactamase inhibitors (i.e., clavulanic acid, sulbactam, and tazobactam). To explore different mechanisms of inhibition of KPC-2, we determined the cryst...

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Detalhes bibliográficos
Main Authors: Ke, Wei, Bethel, Christopher R., Papp-Wallace, Krisztina M., Pagadala, Sundar Ram Reddy, Nottingham, Micheal, Fernandez, Daniel, Buynak, John D., Bonomo, Robert A., van den Akker, Focco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346646/
https://ncbi.nlm.nih.gov/pubmed/22330909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06099-11
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