Strategic Design of an Effective β-Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2′-SUBSTITUTED PENICILLIN SULFONE

In an effort to devise strategies for overcoming bacterial β-lactamases, we studied LN-1-255, a 6-alkylidene-2′-substituted penicillin sulfone inhibitor. By possessing a catecholic functionality that resembles a natural bacterial siderophore, LN-1-255 is unique among β-lactamase inhibitors. LN-1-255...

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Detalhes bibliográficos
Main Authors: Pattanaik, Priyaranjan, Bethel, Christopher R., Hujer, Andrea M., Hujer, Kristine M., Distler, Anne M., Taracila, Magdalena, Anderson, Vernon E., Fritsche, Thomas R., Jones, Ronald N., Pagadala, Sundar Ram Reddy, van den Akker, Focco, Buynak, John D., Bonomo, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613614/
https://ncbi.nlm.nih.gov/pubmed/18955486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806833200
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