Design, Synthesis and Crystal Structures of 6-Alkylidene-2’-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 Carbapenemase

Class D β-lactamases represent a growing and diverse class of penicillin inactivating enzymes that are usually resistant to commercial β-lactamase inhibitors. As many such enzymes are found in multi-drug resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa, novel β-lactamase inhibitors...

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Main Authors: Bou, German, Santillana, Elena, Sheri, Anjaneyulu, Beceiro, Alejandro, Sampson, Jared, Kalp, Matthew, Bethel, Christopher R., Distler, Anne M., Drawz, Sarah M., Pagadala, Sundar Ram Reddy, van den Akker, Focco, Bonomo, Robert A., Romero, Antonio, Buynak, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393087/
https://ncbi.nlm.nih.gov/pubmed/20822105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja104092z
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