Three Decades of β-Lactamase Inhibitors

di Drawz, Sarah M., Bonomo, Robert A.
Pubblicazione 2010

New β-Lactamase Inhibitors: a Therapeutic Renaissance in an MDR World

di Drawz, Sarah M., Papp-Wallace, Krisztina M., Bonomo, Robert A.
Pubblicazione 2014

Susceptibility to Alternative Oral Antimicrobial Agents in Relation to Sequence Type ST131 Status and Coresistance Phenotype among Recent Escherichia coli Isolates from U.S. Vetera...

di Johnson, James R., Drawz, Sarah M., Porter, Stephen, Kuskowski, Michael A.
Pubblicazione 2013

Exploring sequence requirements for C(3)/C(4) carboxylate recognition in the Pseudomonas aeruginosa cephalosporinase: Insights into plasticity of the AmpC β-lactamase

di Drawz, Sarah M, Taracila, Magdalena, Caselli, Emilia, Prati, Fabio, Bonomo, Robert A
Pubblicazione 2011

Novel β-lactamase inhibitors: a therapeutic hope against the scourge of multidrug resistance

di Watkins, Richard R., Papp-Wallace, Krisztina M., Drawz, Sarah M., Bonomo, Robert A.
Pubblicazione 2013

Crystal Structure of a Preacylation Complex of the β-Lactamase Inhibitor Sulbactam Bound to a Sulfenamide Bond-Containing Thiol-β-lactamase

di Rodkey, Elizabeth A., Drawz, Sarah M., Sampson, Jared M., Bethel, Christopher R., Bonomo, Robert A., van den Akker, Focco
Pubblicazione 2012

Variation in Resistance Traits, Phylogenetic Backgrounds, and Virulence Genotypes among Escherichia coli Clinical Isolates from Adjacent Hospital Campuses Serving Distinct Patient...

di Drawz, Sarah M., Porter, Stephen, Kuskowski, Michael A., Johnston, Brian, Clabots, Connie, Kline, Susan, Ferrieri, Patricia, Johnson, James R.
Pubblicato in Antimicrob Agents Chemother (2015)

Inhibition of the Class C β-Lactamase from Acinetobacter spp: Insights into Effective Inhibitor Design

di Drawz, Sarah M., Babic, Maja, Bethel, Christopher R., Taracila, Magda, Distler, Anne M., Ori, Claudia, Caselli, Emilia, Prati, Fabio, Bonomo, Robert A.
Pubblicazione 2010

Novel Insights into the Mode of Inhibition of Class A SHV-1 β-Lactamases Revealed by Boronic Acid Transition State Inhibitors

di Ke, Wei, Sampson, Jared M., Ori, Claudia, Prati, Fabio, Drawz, Sarah M., Bethel, Christopher R., Bonomo, Robert A., van den Akker, Focco
Pubblicazione 2011

The Role of a Second-Shell Residue in Modifying Substrate and Inhibitor Interactions in the SHV β-Lactamase: A Study of Ambler Position Asn276()

di Drawz, Sarah M., Bethel, Christopher R., Hujer, Kristine M., Hurless, Kelly N., Distler, Anne M., Caselli, Emilia, Prati, Fabio, Bonomo, Robert A.
Pubblicazione 2009

Resistance Emergence Mechanism and Mechanism of Resistance Suppression by Tobramycin for Cefepime for Pseudomonas aeruginosa

di Drusano, G. L., Bonomo, Robert A., Bahniuk, Nadzeya, Bulitta, Juergen B., VanScoy, Brian, DeFiglio, Holland, Fikes, Steven, Brown, David, Drawz, Sarah M., Kulawy, Robert, Louie, Arnold
Pubblicazione 2012

Modifications of the C6-Substituent of Penicillin Sulfones with the Goal of Improving Inhibitor Recognition and Efficacy

di Nottingham, Micheal, Bethel, Christopher R., Pagadala, Sundar Ram Reddy, Harry, Emily, Pinto, Abishai, Lemons, Zachary A., Drawz, Sarah M., van den Akker, Focco, Carey, Paul R., Bonomo, Robert A., Buynak, John D.
Pubblicazione 2010

Penicillin Sulfone Inhibitors of Class D β-Lactamases

di Drawz, Sarah M., Bethel, Christopher R., Doppalapudi, Venkata R., Sheri, Anjaneyulu, Pagadala, Sundar Ram Reddy, Hujer, Andrea M., Skalweit, Marion J., Anderson, Vernon E., Chen, Shu G., Buynak, John D., Bonomo, Robert A.
Pubblicazione 2010

Enhancing Resistance to Cephalosporins in class C β-lactamases: impact of Glu214Gly in CMY-2

di Endimiani, Andrea, Doi, Yohei, Bethel, Christopher R., Taracila, Magdalena, Adams-Haduch, Jennifer M., O'Keefe, Alexandra, Hujer, Andrea M., Paterson, David L., Skalweit, Marion J., Page, Malcolm G. P., Drawz, Sarah M., Bonomo, Robert A.
Pubblicazione 2010

Design, Synthesis and Crystal Structures of 6-Alkylidene-2’-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 Carbapenemase

di Bou, German, Santillana, Elena, Sheri, Anjaneyulu, Beceiro, Alejandro, Sampson, Jared, Kalp, Matthew, Bethel, Christopher R., Distler, Anne M., Drawz, Sarah M., Pagadala, Sundar Ram Reddy, van den Akker, Focco, Bonomo, Robert A., Romero, Antonio, Buynak, John D.
Pubblicazione 2010

Design and Exploration of Novel Boronic Acid Inhibitors Reveals Important Interactions with a Clavulanic Acid-Resistant Sulfhydryl-Variable (SHV) β-Lactamase

di Winkler, Marisa L., Rodkey, Elizabeth A., Taracila, Magdalena A., Drawz, Sarah M., Bethel, Christopher R., Papp-Wallace, Krisztina M., Smith, Kerri M., Xu, Yan, Dwulit-Smith, Jeffrey R., Romagnoli, Chiara, Caselli, Emilia, Prati, Fabio, van den Akker, Focco, Bonomo, Robert A.
Pubblicazione 2013

Inactivation of a class A and a class C β-lactamase by 6β-(hydroxymethyl)penicillanic acid sulfone

di Papp-Wallace, Krisztina M., Bethel, Christopher R., Gootz, Thomas D., Shang, Wenchi, Stroh, Justin, Lau, William, McLeod, Dale, Price, Loren, Marfat, Anthony, Distler, Anne, Drawz, Sarah M., Chen, Hansong, Harry, Emily, Nottingham, Micheal, Carey, Paul R., Buynak, John D., Bonomo, Robert A.
Pubblicazione 2011