Novel Insights into the Mode of Inhibition of Class A SHV-1 β-Lactamases Revealed by Boronic Acid Transition State Inhibitors

Boronic acid transition state inhibitors (BATSIs) are potent class A and C β-lactamase inactivators and are of particular interest due to their reversible nature mimicking the transition state. Here, we present structural and kinetic data describing the inhibition of the SHV-1 β-lactamase, a clinica...

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Detalhes bibliográficos
Main Authors: Ke, Wei, Sampson, Jared M., Ori, Claudia, Prati, Fabio, Drawz, Sarah M., Bethel, Christopher R., Bonomo, Robert A., van den Akker, Focco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019678/
https://ncbi.nlm.nih.gov/pubmed/21041505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00930-10
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