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Crystal Structure of a Preacylation Complex of the β-Lactamase Inhibitor Sulbactam Bound to a Sulfenamide Bond-Containing Thiol-β-lactamase

The rise of inhibitor-resistant and other β-lactamase variants is generating an interest in developing new β-lactamase inhibitors to complement currently available antibiotics. To gain insight into the chemistry of inhibitor recognition, we determined the crystal structure of the inhibitor preacylat...

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Bibliographic Details
Main Authors: Rodkey, Elizabeth A., Drawz, Sarah M., Sampson, Jared M., Bethel, Christopher R., Bonomo, Robert A., van den Akker, Focco
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4037319/
https://ncbi.nlm.nih.gov/pubmed/22974281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3073676
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