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Crystal structure of KPC-2: insights into carbapenemase activity in Class A β-lactamases

β-lactamases inactivate β-lactam antibiotics and are a major cause of antibiotic resistance. The recent outbreaks of Klebsiella pneumoniae carbapenem-resistant (KPC) infections mediated by KPC type β-lactamases are creating a serious threat to our “last resort” antibiotics, the carbapenems. KPC β-la...

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Detalhes bibliográficos
Main Authors: Ke, Wei, Bethel, Christopher R., Thomson, Jodi M., Bonomo, Robert A., van den Akker, Focco
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596071/
https://ncbi.nlm.nih.gov/pubmed/17441734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi700300u
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