Design and Exploration of Novel Boronic Acid Inhibitors Reveals Important Interactions with a Clavulanic Acid-Resistant Sulfhydryl-Variable (SHV) β-Lactamase

[Image: see text] Inhibitor resistant (IR) class A β-lactamases pose a significant threat to many current antibiotic combinations. The K234R substitution in the SHV β-lactamase, from Klebsiella pneumoniae, results in resistance to ampicillin/clavulanate. After site-saturation mutagenesis of Lys-234...

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Autors principals: Winkler, Marisa L., Rodkey, Elizabeth A., Taracila, Magdalena A., Drawz, Sarah M., Bethel, Christopher R., Papp-Wallace, Krisztina M., Smith, Kerri M., Xu, Yan, Dwulit-Smith, Jeffrey R., Romagnoli, Chiara, Caselli, Emilia, Prati, Fabio, van den Akker, Focco, Bonomo, Robert A.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943433/
https://ncbi.nlm.nih.gov/pubmed/23252553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301490d
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