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Use of Novel Boronic Acid Transition State Inhibitors To Probe Substrate Affinity in SHV-Type Extended-Spectrum β-Lactamases
Boronic acid transition state inhibitors (BATSIs) with R1 side chains of cefotaxime and ceftazidime were assayed against SHV-1, SHV-2, SHV-5, D104K, and D104K G238S β-lactamases. The D104K variant was the most susceptible to inhibition by the ceftazidime BATSI (K(i), 730 ± 80 nM), while the D104K G2...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1855462/ https://ncbi.nlm.nih.gov/pubmed/17220410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01293-06 |
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