Role of Asp104 in the SHV β-Lactamase

Among the TEM-type extended-spectrum β-lactamases (ESBLs), an amino acid change at Ambler position 104 (Glu to Lys) results in increased resistance to ceftazidime and cefotaxime when found with other substitutions (e.g., Gly238Ser and Arg164Ser). To examine the role of Asp104 in SHV β-lactamases, si...

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Detalhes bibliográficos
Main Authors: Bethel, Christopher R., Hujer, Andrea M., Hujer, Kristine M., Thomson, Jodi M., Ruszczycky, Mark W., Anderson, Vernon E., Pusztai-Carey, Marianne, Taracila, Magdalena, Helfand, Marion S., Bonomo, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1694000/
https://ncbi.nlm.nih.gov/pubmed/16982784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00848-06
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