Role of Asp104 in the SHV β-Lactamase

Among the TEM-type extended-spectrum β-lactamases (ESBLs), an amino acid change at Ambler position 104 (Glu to Lys) results in increased resistance to ceftazidime and cefotaxime when found with other substitutions (e.g., Gly238Ser and Arg164Ser). To examine the role of Asp104 in SHV β-lactamases, si...

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Autors principals: Bethel, Christopher R., Hujer, Andrea M., Hujer, Kristine M., Thomson, Jodi M., Ruszczycky, Mark W., Anderson, Vernon E., Pusztai-Carey, Marianne, Taracila, Magdalena, Helfand, Marion S., Bonomo, Robert A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1694000/
https://ncbi.nlm.nih.gov/pubmed/16982784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00848-06
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