Amino Acid Substitutions at Ambler Position Gly238 in the SHV-1 β-Lactamase: Exploring Sequence Requirements for Resistance to Penicillins and Cephalosporins

Site saturation mutagenesis of the 238 position in the SHV β-lactamase was performed to identify the complete sequence requirements needed for the extended spectrum β-lactamase (ESBL) phenotype. MICs (in micrograms per milliliter) in an isogenic background, Escherichia coli DH10B, demonstrated that...

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Detalhes bibliográficos
Main Authors: Hujer, Andrea M., Hujer, Kristine M., Helfand, Marion S., Anderson, Vernon E., Bonomo, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC132793/
https://ncbi.nlm.nih.gov/pubmed/12435703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.12.3971-3977.2002
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