Inhibition of OXA-1 β-Lactamase by Penems

The partnering of a β-lactam with a β-lactamase inhibitor is a highly effective strategy that can be used to combat bacterial resistance to β-lactam antibiotics mediated by serine β-lactamases (EC 3.2.5.6). To this end, we tested two novel penem inhibitors against OXA-1, a class D β-lactamase that i...

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Detalhes bibliográficos
Main Authors: Bethel, Christopher R., Distler, Anne M., Ruszczycky, Mark W., Carey, Marianne P., Carey, Paul R., Hujer, Andrea M., Taracila, Magda, Helfand, Marion S., Thomson, Jodi M., Kalp, Matthew, Anderson, Vernon E., Leonard, David A., Hujer, Kristine M., Abe, Takao, Venkatesan, Aranapakam M., Mansour, Tarek S., Bonomo, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533510/
https://ncbi.nlm.nih.gov/pubmed/18559643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01677-07
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