In Vitro and In Vivo Activities of Novel 6-Methylidene Penems as β-Lactamase Inhibitors

Novel penem molecules with heterocycle substitutions at the 6 position via a methylidene linkage were investigated for their activities and efficacy as β-lactamase inhibitors. The concentrations of these molecules that resulted in 50% inhibition of enzyme activity were 0.4 to 3.1 nM for the TEM-1 en...

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Detalhes bibliográficos
Main Authors: Weiss, William J., Petersen, Peter J., Murphy, Timothy M., Tardio, LuAnna, Yang, Youjun, Bradford, Patricia A., Venkatesan, Aranapakam M., Abe, Takao, Isoda, Takeshi, Mihira, Ado, Ushirogochi, Hideki, Takasake, Tsuyoshi, Projan, Steve, O'Connell, John, Mansour, Tarek S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC529194/
https://ncbi.nlm.nih.gov/pubmed/15561830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4589-4596.2004
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