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Efficacy of Piperacillin Combined with the Penem β-Lactamase Inhibitor BLI-489 in Murine Models of Systemic Infection

The in vivo efficacy of piperacillin in combination with the penem inhibitor BLI-489 was determined using acute lethal systemic infections in mice. On the basis of preliminary results with various ratios, a dosing ratio of 8:1 was found to be optimal for retention of enhanced efficacy. Piperacillin-...

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Detalhes bibliográficos
Main Authors: Petersen, Peter J., Jones, C. Hal, Venkatesan, Aranapakam M., Bradford, Patricia A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663108/
https://ncbi.nlm.nih.gov/pubmed/19188386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01549-08
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