In Vitro and In Vivo Activities of Novel 6-Methylidene Penems as β-Lactamase Inhibitors

Novel penem molecules with heterocycle substitutions at the 6 position via a methylidene linkage were investigated for their activities and efficacy as β-lactamase inhibitors. The concentrations of these molecules that resulted in 50% inhibition of enzyme activity were 0.4 to 3.1 nM for the TEM-1 en...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Weiss, William J., Petersen, Peter J., Murphy, Timothy M., Tardio, LuAnna, Yang, Youjun, Bradford, Patricia A., Venkatesan, Aranapakam M., Abe, Takao, Isoda, Takeshi, Mihira, Ado, Ushirogochi, Hideki, Takasake, Tsuyoshi, Projan, Steve, O'Connell, John, Mansour, Tarek S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Susceptibility
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC529194/
https://ncbi.nlm.nih.gov/pubmed/15561830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4589-4596.2004
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items