Inhibition of OXA-1 β-Lactamase by Penems

The partnering of a β-lactam with a β-lactamase inhibitor is a highly effective strategy that can be used to combat bacterial resistance to β-lactam antibiotics mediated by serine β-lactamases (EC 3.2.5.6). To this end, we tested two novel penem inhibitors against OXA-1, a class D β-lactamase that i...

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Main Authors: Bethel, Christopher R., Distler, Anne M., Ruszczycky, Mark W., Carey, Marianne P., Carey, Paul R., Hujer, Andrea M., Taracila, Magda, Helfand, Marion S., Thomson, Jodi M., Kalp, Matthew, Anderson, Vernon E., Leonard, David A., Hujer, Kristine M., Abe, Takao, Venkatesan, Aranapakam M., Mansour, Tarek S., Bonomo, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533510/
https://ncbi.nlm.nih.gov/pubmed/18559643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01677-07
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