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Inhibition of the Class C β-Lactamase from Acinetobacter spp: Insights into Effective Inhibitor Design

The need to develop β-lactamase inhibitors against class C cephalosporinases of Gram-negative pathogens represents an urgent clinical priority. To respond to this challenge, five boronic acid derivatives including a new cefoperazone analog were synthesized and tested against the class C cephalospori...

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Détails bibliographiques
Auteurs principaux: Drawz, Sarah M., Babic, Maja, Bethel, Christopher R., Taracila, Magda, Distler, Anne M., Ori, Claudia, Caselli, Emilia, Prati, Fabio, Bonomo, Robert A.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810401/
https://ncbi.nlm.nih.gov/pubmed/19925018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9015988
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