Penicillin Sulfone Inhibitors of Class D β-Lactamases

OXA β-lactamases are largely responsible for β-lactam resistance in Acinetobacter spp. and Pseudomonas aeruginosa, two of the most difficult-to-treat nosocomial pathogens. In general, the β-lactamase inhibitors used in clinical practice (clavulanic acid, sulbactam, and tazobactam) demonstrate poor a...

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Detalhes bibliográficos
Main Authors: Drawz, Sarah M., Bethel, Christopher R., Doppalapudi, Venkata R., Sheri, Anjaneyulu, Pagadala, Sundar Ram Reddy, Hujer, Andrea M., Skalweit, Marion J., Anderson, Vernon E., Chen, Shu G., Buynak, John D., Bonomo, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849368/
https://ncbi.nlm.nih.gov/pubmed/20086146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00743-09
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