Penicillin Sulfone Inhibitors of Class D β-Lactamases

OXA β-lactamases are largely responsible for β-lactam resistance in Acinetobacter spp. and Pseudomonas aeruginosa, two of the most difficult-to-treat nosocomial pathogens. In general, the β-lactamase inhibitors used in clinical practice (clavulanic acid, sulbactam, and tazobactam) demonstrate poor a...

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Bibliografiske detaljer
Main Authors: Drawz, Sarah M., Bethel, Christopher R., Doppalapudi, Venkata R., Sheri, Anjaneyulu, Pagadala, Sundar Ram Reddy, Hujer, Andrea M., Skalweit, Marion J., Anderson, Vernon E., Chen, Shu G., Buynak, John D., Bonomo, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849368/
https://ncbi.nlm.nih.gov/pubmed/20086146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00743-09
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