Penicillin Sulfone Inhibitors of Class D β-Lactamases

OXA β-lactamases are largely responsible for β-lactam resistance in Acinetobacter spp. and Pseudomonas aeruginosa, two of the most difficult-to-treat nosocomial pathogens. In general, the β-lactamase inhibitors used in clinical practice (clavulanic acid, sulbactam, and tazobactam) demonstrate poor a...

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Autori principali: Drawz, Sarah M., Bethel, Christopher R., Doppalapudi, Venkata R., Sheri, Anjaneyulu, Pagadala, Sundar Ram Reddy, Hujer, Andrea M., Skalweit, Marion J., Anderson, Vernon E., Chen, Shu G., Buynak, John D., Bonomo, Robert A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
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Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849368/
https://ncbi.nlm.nih.gov/pubmed/20086146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00743-09
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