Strategic Design of an Effective β-Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2′-SUBSTITUTED PENICILLIN SULFONE

In an effort to devise strategies for overcoming bacterial β-lactamases, we studied LN-1-255, a 6-alkylidene-2′-substituted penicillin sulfone inhibitor. By possessing a catecholic functionality that resembles a natural bacterial siderophore, LN-1-255 is unique among β-lactamase inhibitors. LN-1-255...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pattanaik, Priyaranjan, Bethel, Christopher R., Hujer, Andrea M., Hujer, Kristine M., Distler, Anne M., Taracila, Magdalena, Anderson, Vernon E., Fritsche, Thomas R., Jones, Ronald N., Pagadala, Sundar Ram Reddy, van den Akker, Focco, Buynak, John D., Bonomo, Robert A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2009
Gaiak:
Enzyme Catalysis and Regulation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613614/
https://ncbi.nlm.nih.gov/pubmed/18955486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806833200
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