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The Effect of the Inhibitor–Resistant M69V Substitution on the Structures and Populations of Trans–Enamine β-Lactamase Intermediates

The objective of this study is to determine the molecular factors that lead to β-lactamase inhibitor resistance for the variant M69V in SHV-1 β-lactamase. With mechanism-based inhibitors, the β-lactamase forms an acyl-enzyme that consists of a trans-enamine derivative in the active site. The present...

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Hlavní autoři: Totir, Monica A., Padayatti, Pius S., Helfand, Marion S., Carey, Marianne P., Bonomo, Robert A., Carey, Paul R., van den Akker, Focco
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596060/
https://ncbi.nlm.nih.gov/pubmed/17002290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060990m
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