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The Effect of the Inhibitor–Resistant M69V Substitution on the Structures and Populations of Trans–Enamine β-Lactamase Intermediates
The objective of this study is to determine the molecular factors that lead to β-lactamase inhibitor resistance for the variant M69V in SHV-1 β-lactamase. With mechanism-based inhibitors, the β-lactamase forms an acyl-enzyme that consists of a trans-enamine derivative in the active site. The present...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596060/ https://ncbi.nlm.nih.gov/pubmed/17002290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060990m |
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