Exploring Additional Dimensions of Complexity in Inhibitor Design for Serine β-Lactamases: Mechanistic and Intra- and Inter-molecular Chemistry Approaches

As a bacterial resistance strategy, serine β-lactamases have evolved from cell wall synthesizing enzymes known as penicillin-binding proteins (PBP), by not only covalently binding β-lactam antibiotics but, also acquiring mechanisms of deacylating these antibiotics. This critical deacylation step lea...

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Udgivet i:Front Microbiol
Main Authors: van den Akker, Focco, Bonomo, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895744/
https://ncbi.nlm.nih.gov/pubmed/29675000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.00622
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