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Approaches to the simultaneous inactivation of metallo-and serine-β-lactamases
A series of cephalosporin-derived reverse hydroxamates and oximes were prepared and evaluated as inhibitors of representative metallo- and serine-β-lactamases. The reverse hydroxamates showed submicromolar inhibition of the GIM-1 metallo-β-lactamase. With respect to interactions with the classes A,...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896329/ https://ncbi.nlm.nih.gov/pubmed/19243936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.02.018 |
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