Kinetic Characterization of VIM-7, a Divergent Member of the VIM Metallo-β-Lactamase Family

Purified recombinant VIM-7 possesses efficient penicillinase and carbapenemase activities comparable to those of VIM-2. Cephalosporinase activity was variable and generally lower than those of VIM-1 and VIM-2. A homology model suggests that the VIM-7 Tyr-218 Phe substitution may be responsible for t...

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Bibliografiske detaljer
Main Authors: Samuelsen, Ørjan, Castanheira, Mariana, Walsh, Timothy R., Spencer, James
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493091/
https://ncbi.nlm.nih.gov/pubmed/18559652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00166-08
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