His224 Alters the R2 Drug Binding Site and Phe218 Influences the Catalytic Efficiency of the Metallo-β-Lactamase VIM-7

Metallo-β-lactamases (MBLs) are the causative mechanism for resistance to β-lactams, including carbapenems, in many Gram-negative pathogenic bacteria. One important family of MBLs is the Verona integron-encoded MBLs (VIM). In this study, the importance of residues Asp120, Phe218, and His224 in the m...

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Detalhes bibliográficos
Main Authors: Leiros, Hanna-Kirsti S., Skagseth, Susann, Edvardsen, Kine Susann Waade, Lorentzen, Marit Sjo, Bjerga, Gro Elin Kjæreng, Leiros, Ingar, Samuelsen, Ørjan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136046/
https://ncbi.nlm.nih.gov/pubmed/24913158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02735-13
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