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Role of Residues W228 and Y233 in the Structure and Activity of Metallo-β-Lactamase GIM-1
Metallo-β-lactamases (MBLs) hydrolyze virtually all β-lactam antibiotics, including penicillins, cephalosporins, and carbapenems. The worldwide emergence of antibiotic-resistant bacteria harboring MBLs poses an increasing clinical threat. The MBL German imipenemase-1 (GIM-1) possesses an active site...
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| Publicado no: | Antimicrob Agents Chemother |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4750685/ https://ncbi.nlm.nih.gov/pubmed/26643332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02017-15 |
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