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Structural Insights into TMB-1 and the Role of Residues 119 and 228 in Substrate and Inhibitor Binding
Metallo-β-lactamases (MBLs) threaten the effectiveness of β-lactam antibiotics, including carbapenems, and are a concern for global public health. β-Lactam/β-lactamase inhibitor combinations active against class A and class D carbapenemases are used, but no clinically useful MBL inhibitor is current...
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| Publicado no: | Antimicrob Agents Chemother |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5527624/ https://ncbi.nlm.nih.gov/pubmed/28559248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02602-16 |
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