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Structural Insights into TMB-1 and the Role of Residues 119 and 228 in Substrate and Inhibitor Binding

Metallo-β-lactamases (MBLs) threaten the effectiveness of β-lactam antibiotics, including carbapenems, and are a concern for global public health. β-Lactam/β-lactamase inhibitor combinations active against class A and class D carbapenemases are used, but no clinically useful MBL inhibitor is current...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Skagseth, Susann, Christopeit, Tony, Akhter, Sundus, Bayer, Annette, Samuelsen, Ørjan, Leiros, Hanna-Kirsti S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527624/
https://ncbi.nlm.nih.gov/pubmed/28559248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02602-16
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