His224 Alters the R2 Drug Binding Site and Phe218 Influences the Catalytic Efficiency of the Metallo-β-Lactamase VIM-7

Metallo-β-lactamases (MBLs) are the causative mechanism for resistance to β-lactams, including carbapenems, in many Gram-negative pathogenic bacteria. One important family of MBLs is the Verona integron-encoded MBLs (VIM). In this study, the importance of residues Asp120, Phe218, and His224 in the m...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Leiros, Hanna-Kirsti S., Skagseth, Susann, Edvardsen, Kine Susann Waade, Lorentzen, Marit Sjo, Bjerga, Gro Elin Kjæreng, Leiros, Ingar, Samuelsen, Ørjan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136046/
https://ncbi.nlm.nih.gov/pubmed/24913158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02735-13
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars