Meropenem and Chromacef Intermediates Observed in IMP-25 Metallo-β-Lactamase-Catalyzed Hydrolysis

Metallo-β-lactamases inactivate most β-lactam antibacterials, and much attention has been paid to their catalytic mechanism. One issue of controversy has been whether β-lactam hydrolysis generally proceeds through an anionic intermediate bound to the active-site Zn(II) ions or not. The formation of...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Oelschlaeger, Peter, Aitha, Mahesh, Yang, Hao, Kang, Joon S., Zhang, Antonia L., Liu, Eleanor M., Buynak, John D., Crowder, Michael W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468739/
https://ncbi.nlm.nih.gov/pubmed/25918145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04409-14
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