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A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases
Carbapenem-resistant Enterobacteriaceae threaten human health, since carbapenems are last resort drugs for infections by such organisms. Metallo-β-lactamases (MβLs) are the main mechanism of resistance against carbapenems. Clinically approved inhibitors of MBLs are currently unavailable as design ha...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5599593/ https://ncbi.nlm.nih.gov/pubmed/28912448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00601-9 |
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