A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases

Carbapenem-resistant Enterobacteriaceae threaten human health, since carbapenems are last resort drugs for infections by such organisms. Metallo-β-lactamases (MβLs) are the main mechanism of resistance against carbapenems. Clinically approved inhibitors of MBLs are currently unavailable as design ha...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Lisa, María-Natalia, Palacios, Antonela R., Aitha, Mahesh, González, Mariano M., Moreno, Diego M., Crowder, Michael W., Bonomo, Robert A., Spencer, James, Tierney, David L., Llarrull, Leticia I., Vila, Alejandro J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599593/
https://ncbi.nlm.nih.gov/pubmed/28912448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00601-9
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg