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A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases
Carbapenem-resistant Enterobacteriaceae threaten human health, since carbapenems are last resort drugs for infections by such organisms. Metallo-β-lactamases (MβLs) are the main mechanism of resistance against carbapenems. Clinically approved inhibitors of MBLs are currently unavailable as design ha...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5599593/ https://ncbi.nlm.nih.gov/pubmed/28912448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00601-9 |
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