Engineered Mononuclear Variants in Bacillus cereus Metallo-β-lactamase BcII Are Inactive

Metallo-β-lactamases (MβLs) are zinc enzymes able to hydrolyze almost all β-lactam antibiotics, rendering them inactive, at the same time endowing bacteria high levels of resistance. The design of inhibitors active against all classes of MβLs has been hampered by their structural diversity and by th...

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Bibliografiske detaljer
Main Authors: Abriata, Luciano A., González, Lisandro J., Llarrull, Leticia I., Tomatis, Pablo E., Myers, William K., Costello, Alison L., Tierney, David L., Vila, Alejandro J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565585/
https://ncbi.nlm.nih.gov/pubmed/18652482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8006912
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