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Engineered Mononuclear Variants in Bacillus cereus Metallo-β-lactamase BcII Are Inactive
Metallo-β-lactamases (MβLs) are zinc enzymes able to hydrolyze almost all β-lactam antibiotics, rendering them inactive, at the same time endowing bacteria high levels of resistance. The design of inhibitors active against all classes of MβLs has been hampered by their structural diversity and by th...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2565585/ https://ncbi.nlm.nih.gov/pubmed/18652482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8006912 |
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