A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases

Carbapenem-resistant Enterobacteriaceae threaten human health, since carbapenems are last resort drugs for infections by such organisms. Metallo-β-lactamases (MβLs) are the main mechanism of resistance against carbapenems. Clinically approved inhibitors of MBLs are currently unavailable as design ha...

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Udgivet i:Nat Commun
Main Authors: Lisa, María-Natalia, Palacios, Antonela R., Aitha, Mahesh, González, Mariano M., Moreno, Diego M., Crowder, Michael W., Bonomo, Robert A., Spencer, James, Tierney, David L., Llarrull, Leticia I., Vila, Alejandro J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599593/
https://ncbi.nlm.nih.gov/pubmed/28912448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00601-9
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