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Probing substrate binding to the metal binding sites in metallo-β-lactamase L1 during catalysis
Metal ions in metallo-β-lactamases (MBLs) play a major role in catalysis. In this study we investigated the role of the metal ions in the Zn(1) and Zn(2) sites of MBL L1 during catalysis. A ZnCo (with Zn(II) in the invariant Zn(1) site and Co(II) in the Zn(2) site) analog of MBL L1 was prepared by u...
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| Опубликовано в: : | Medchemcomm |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4830629/ https://ncbi.nlm.nih.gov/pubmed/27087914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C5MD00358J |
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