New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases

Por Canning, Peter, Bullock, Alex N.
Publicado em 2014

Targeting RIPK1,2,3 to combat inflammation

Por Bullock, Alex N., Degterev, Alexei
Publicado no Oncotarget (2015)

Structural Basis of Intracellular TGF-β Signaling: Receptors and Smads

Por Chaikuad, Apirat, Bullock, Alex N.
Publicado no Cold Spring Harb Perspect Biol (2016)

Structural Basis for ASPP2 Recognition by the Tumor Suppressor p73

Por Canning, Peter, von Delft, Frank, Bullock, Alex N.
Publicado em 2012

Structural basis of Keap1 interactions with Nrf2

Por Canning, Peter, Sorrell, Fiona J., Bullock, Alex N.
Publicado no Free Radic Biol Med (2015)

ACVR1 mutations in DIPG: lessons learned from FOP

Por Taylor, Kathryn R, Vinci, Maria, Bullock, Alex N, Jones, Chris
Publicado em 2014

Crystal structure of the SOCS2–elongin C–elongin B complex defines a prototypical SOCS box ubiquitin ligase

Por Bullock, Alex N., Debreczeni, Judit É., Edwards, Aled M., Sundström, Michael, Knapp, Stefan
Publicado em 2006

Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation

Por Bullock, Alex N., Rodriguez, Maria C., Debreczeni, Judit É., Songyang, Zhou, Knapp, Stefan
Publicado em 2007

Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors

Por Canning, Peter, Tan, Li, Chu, Kiki, Lee, Sam W., Gray, Nathanael S., Bullock, Alex N.
Publicado em 2014

Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation

Por Schumacher, Frances-Rose, Sorrell, Fiona J., Alessi, Dario R., Bullock, Alex N., Kurz, Thimo
Publicado em 2014

Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding

Por Dixon-Clarke, Sarah E., Elkins, Jonathan M., Cheng, S.-W. Grace, Morin, Gregg B., Bullock, Alex N.
Publicado no Sci Rep (2015)

Development of an ALK2-biased BMP type I receptor kinase inhibitor

Por Mohedas, Agustin H., Xing, Xuechao, Armstrong, Kelli A., Bullock, Alex N., Cuny, Gregory D., Yu, Paul B.
Publicado em 2013

A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis

Por Kerr, Georgina, Sheldon, Helen, Chaikuad, Apirat, Alfano, Ivan, von Delft, Frank, Bullock, Alex N., Harris, Adrian L.
Publicado no Angiogenesis (2015)

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

Por Fedorov, Oleg, Marsden, Brian, Pogacic, Vanda, Rellos, Peter, Müller, Susanne, Bullock, Alex N., Schwaller, Juerg, Sundström, Michael, Knapp, Stefan
Publicado em 2007

Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases

Por Muniz, João R.C., Guo, Kunde, Kershaw, Nadia J., Ayinampudi, Vikram, von Delft, Frank, Babon, Jeffrey J., Bullock, Alex N.
Publicado em 2013

Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation

Por Horbelt, Daniel, Boergermann, Jan H., Chaikuad, Apirat, Alfano, Ivan, Williams, Eleanor, Lukonin, Ilya, Timmel, Tobias, Bullock, Alex N., Knaus, Petra
Publicado no J Biol Chem (2015)

Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16

Por Dixon-Clarke, Sarah E., Shehata, Saifeldin N., Krojer, Tobias, Sharpe, Timothy D., vonDelft, Frank, Sakamoto, Kei, Bullock, Alex N.
Publicado no Biochem J (2017)

A novel ACVR1 mutation in the glycine/serine-rich domain found in the most benign case of a fibrodysplasia ossificans progressiva variant reported to date

Por Gregson, Celia L., Hollingworth, Peter, Williams, Martin, Petrie, Kirsten A., Bullock, Alex N., Brown, Matthew A., Tobias, Jon H., Triffitt, James T.
Publicado em 2010

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

Por Baumli, Sonja, Lolli, Graziano, Lowe, Edward D, Troiani, Sonia, Rusconi, Luisa, Bullock, Alex N, Debreczeni, Judit É, Knapp, Stefan, Johnson, Louise N
Publicado em 2008

Thermodynamic stability of wild-type and mutant p53 core domain

Por Bullock, Alex N., Henckel, Julia, DeDecker, Brian S., Johnson, Christopher M., Nikolova, Penka V., Proctor, Mark R., Lane, David P., Fersht, Alan R.
Publicado em 1997