A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis

Activin receptor-like kinase 1 (ALK1, encoded by the gene ACVRL1) is a type I BMP/TGF-β receptor that mediates signalling in endothelial cells via phosphorylation of SMAD1/5/8. During angiogenesis, sprouting endothelial cells specialise into tip cells and stalk cells. ALK1 synergises with Notch in s...

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Bibliographic Details
Published in:Angiogenesis
Main Authors: Kerr, Georgina, Sheldon, Helen, Chaikuad, Apirat, Alfano, Ivan, von Delft, Frank, Bullock, Alex N., Harris, Adrian L.
Format: Artigo
Language:Inglês
Published: Springer Netherlands 2015
Subjects:
Brief Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363482/
https://ncbi.nlm.nih.gov/pubmed/25557927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10456-014-9457-y
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