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A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis
Activin receptor-like kinase 1 (ALK1, encoded by the gene ACVRL1) is a type I BMP/TGF-β receptor that mediates signalling in endothelial cells via phosphorylation of SMAD1/5/8. During angiogenesis, sprouting endothelial cells specialise into tip cells and stalk cells. ALK1 synergises with Notch in s...
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| Publicado en: | Angiogenesis |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer Netherlands
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4363482/ https://ncbi.nlm.nih.gov/pubmed/25557927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10456-014-9457-y |
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