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Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation
WNK1 [with no lysine (K)] and WNK4 regulate blood pressure by controlling the activity of ion co-transporters in the kidney. Groundbreaking work has revealed that the ubiquitylation and hence levels of WNK isoforms are controlled by a Cullin-RING E3 ubiquitin ligase complex (CRL3(KLHL3)) that utiliz...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Portland Press Ltd.
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4019986/ https://ncbi.nlm.nih.gov/pubmed/24641320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140153 |
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