Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation

WNK1 [with no lysine (K)] and WNK4 regulate blood pressure by controlling the activity of ion co-transporters in the kidney. Groundbreaking work has revealed that the ubiquitylation and hence levels of WNK isoforms are controlled by a Cullin-RING E3 ubiquitin ligase complex (CRL3(KLHL3)) that utiliz...

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Bibliographic Details
Main Authors: Schumacher, Frances-Rose, Sorrell, Fiona J., Alessi, Dario R., Bullock, Alex N., Kurz, Thimo
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019986/
https://ncbi.nlm.nih.gov/pubmed/24641320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140153
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