ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3(Δ403‐459) mutation

Por Murthy, Meena, Kurz, Thimo, O'Shaughnessy, Kevin M.
Publicado no Physiol Rep (2016)

WNK signalling pathways in blood pressure regulation

Por Murthy, Meena, Kurz, Thimo, O’Shaughnessy, Kevin M.
Publicado no Cell Mol Life Sci (2016)

Characterization of the mammalian family of DCN-type NEDD8 E3 ligases

Por Keuss, Matthew J., Thomas, Yann, Mcarthur, Robin, Wood, Nicola T., Knebel, Axel, Kurz, Thimo
Publicado no J Cell Sci (2016)

Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae

Por Siergiejuk, Edyta, Scott, Daniel C, Schulman, Brenda A, Hofmann, Kay, Kurz, Thimo, Peter, Matthias
Publicado em 2009

Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation

Por Schumacher, Frances-Rose, Sorrell, Fiona J., Alessi, Dario R., Bullock, Alex N., Kurz, Thimo
Publicado em 2014

Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

Por Hjerpe, Roland, Thomas, Yann, Chen, Jesse, Zemla, Aleksandra, Curran, Siobhan, Shpiro, Natalia, Dick, Lawrence R., Kurz, Thimo
Publicado em 2012

RNAi Screen for NRF2 Inducers Identifies Targets That Rescue Primary Lung Epithelial Cells from Cigarette Smoke Induced Radical Stress

Por Schumacher, Frances-Rose, Schubert, Steffen, Hannus, Michael, Sönnichsen, Birte, Ittrich, Carina, Kreideweiss, Stefan, Kurz, Thimo, Rippmann, Jörg F.
Publicado no PLoS One (2016)

The TFIIH subunit Tfb3 regulates cullin neddylation

Por Rabut, Gwenaël, Le Dez, Gaëlle, Verma, Rati, Makhnevych, Taras, Knebel, Axel, Kurz, Thimo, Boone, Charles, Deshaies, Raymond J., Peter, Matthias
Publicado em 2011

A dual E3 mechanism for Rub1 ligation to Cdc53

Por Scott, Daniel C., Monda, Julie K., Grace, Christy R. R., Duda, David M., Kriwacki, Richard W., Kurz, Thimo, Schulman, Brenda A.
Publicado em 2010

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt intera...

Por Ohta, Akihito, Schumacher, Frances-Rose, Mehellou, Youcef, Johnson, Clare, Knebel, Axel, Macartney, Thomas J., Wood, Nicola T., Alessi, Dario R., Kurz, Thimo
Publicado em 2013

The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes

Por Meyer-Schaller, Nathalie, Chou, Yang-Chieh, Sumara, Izabela, Martin, Dale D. O., Kurz, Thimo, Katheder, Nadja, Hofmann, Kay, Berthiaume, Luc G., Sicheri, Frank, Peter, Matthias
Publicado em 2009

Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

Por Bett, John S., Ritorto, Maria Stella, Ewan, Richard, Jaffray, Ellis G., Virdee, Satpal, Chin, Jason W., Knebel, Axel, Kurz, Thimo, Trost, Matthias, Tatham, Michael H., Hay, Ronald T.
Publicado no Biochem J (2015)

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia

Por Schumacher, Frances-Rose, Siew, Keith, Zhang, Jinwei, Johnson, Clare, Wood, Nicola, Cleary, Sarah E, Al Maskari, Raya S, Ferryman, James T, Hardege, Iris, Figg, Nichola L, Enchev, Radoslav, Knebel, Axel, O’Shaughnessy, Kevin M, Kurz, Thimo
Publicado no EMBO Mol Med (2015)

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome

Por Hjerpe, Roland, Bett, John S., Keuss, Matthew J., Solovyova, Alexandra, McWilliams, Thomas G., Johnson, Clare, Sahu, Indrajit, Varghese, Joby, Wood, Nicola, Wightman, Melanie, Osborne, Georgina, Bates, Gillian P., Glickman, Michael H., Trost, Matthias, Knebel, Axel, Marchesi, Francesco, Kurz, Thimo
Publicado no Cell (2016)

The COP9 signalosome is vital for timely repair of DNA double-strand breaks

Por Meir, Michal, Galanty, Yaron, Kashani, Lior, Blank, Michael, Khosravi, Rami, Fernández-Ávila, María Jesús, Cruz-García, Andrés, Star, Ayelet, Shochot, Lea, Thomas, Yann, Garrett, Lisa J., Chamovitz, Daniel A., Bodine, David M., Kurz, Thimo, Huertas, Pablo, Ziv, Yael, Shiloh, Yosef
Publicado no Nucleic Acids Res (2015)