UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome

Clearance of misfolded and aggregated proteins is central to cell survival. Here, we describe a new pathway for maintaining protein homeostasis mediated by the proteasome shuttle factor UBQLN2. The 26S proteasome degrades polyubiquitylated substrates by recognizing them through stoichiometrically bo...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell
Main Authors: Hjerpe, Roland, Bett, John S., Keuss, Matthew J., Solovyova, Alexandra, McWilliams, Thomas G., Johnson, Clare, Sahu, Indrajit, Varghese, Joby, Wood, Nicola, Wightman, Melanie, Osborne, Georgina, Bates, Gillian P., Glickman, Michael H., Trost, Matthias, Knebel, Axel, Marchesi, Francesco, Kurz, Thimo
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003816/
https://ncbi.nlm.nih.gov/pubmed/27477512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.07.001
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados