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Proteasome in action: substrate degradation by the 26S proteasome

Ubiquitination is the major criteria for the recognition of a substrate-protein by the 26S proteasome. Additionally, a disordered segment on the substrate — either intrinsic or induced — is critical for proteasome engagement. The proteasome is geared to interact with both of these substrate features...

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Detalhes bibliográficos
Publicado no:Biochem Soc Trans
Main Authors: Sahu, Indrajit, Glickman, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106498/
https://ncbi.nlm.nih.gov/pubmed/33729481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20200382
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