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Proteasome in action: substrate degradation by the 26S proteasome

Ubiquitination is the major criteria for the recognition of a substrate-protein by the 26S proteasome. Additionally, a disordered segment on the substrate — either intrinsic or induced — is critical for proteasome engagement. The proteasome is geared to interact with both of these substrate features...

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Pubblicato in:Biochem Soc Trans
Autori principali: Sahu, Indrajit, Glickman, Michael H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106498/
https://ncbi.nlm.nih.gov/pubmed/33729481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20200382
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