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Poly-Ub-Substrate-Degradative Activity of 26S Proteasome Is Not Impaired in the Aging Rat Brain

Proteostasis is critical for the maintenance of life. In neuronal cells an imbalance between protein synthesis and degradation is thought to be involved in the pathogenesis of neurodegenerative diseases during aging. Partly, this seems to be due to a decrease in the activity of the ubiquitin-proteas...

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Detalhes bibliográficos
Main Authors: Giannini, Carolin, Kloß, Alexander, Gohlke, Sabrina, Mishto, Michele, Nicholson, Thomas P., Sheppard, Paul W., Kloetzel, Peter-Michael, Dahlmann, Burkhardt
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646778/
https://ncbi.nlm.nih.gov/pubmed/23667697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064042
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