Poly-Ub-Substrate-Degradative Activity of 26S Proteasome Is Not Impaired in the Aging Rat Brain

Proteostasis is critical for the maintenance of life. In neuronal cells an imbalance between protein synthesis and degradation is thought to be involved in the pathogenesis of neurodegenerative diseases during aging. Partly, this seems to be due to a decrease in the activity of the ubiquitin-proteas...

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Bibliographic Details
Main Authors: Giannini, Carolin, Kloß, Alexander, Gohlke, Sabrina, Mishto, Michele, Nicholson, Thomas P., Sheppard, Paul W., Kloetzel, Peter-Michael, Dahlmann, Burkhardt
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646778/
https://ncbi.nlm.nih.gov/pubmed/23667697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064042
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