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The 26S Proteasome utilizes a kinetic gateway to prioritize substrate degradation
The 26S proteasome is the principal macromolecular machine responsible for protein degradation in eukaryotes. However, little is known about the detailed kinetics and coordination of the underlying substrate-processing steps of the proteasome, and their correlation with observed conformational state...
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| Udgivet i: | Cell |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6519451/ https://ncbi.nlm.nih.gov/pubmed/30929903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.02.031 |
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