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The Cdc48 unfoldase prepares well-folded protein substrates for degradation by the 26S proteasome
Cdc48/p97 is an essential and highly conserved AAA+ ATPase that uses its protein-unfoldase activity to extract ubiquitinated polypeptides from macromolecular complexes and membranes. This motor has also been implicated in protein-degradation pathways, yet its exact role in acting upstream of the 26S...
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| Publicat a: | Commun Biol |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6340886/ https://ncbi.nlm.nih.gov/pubmed/30675527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0283-z |
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