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Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase
The 26S proteasome is the major eukaryotic ATP-dependent protease, yet the detailed mechanisms utilized by the proteasomal heterohexameric AAA+ unfoldase to drive substrate degradation remain poorly understood. To perform systematic mutational analyses of individual ATPase subunits, we heterologousl...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3869383/ https://ncbi.nlm.nih.gov/pubmed/24013205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2659 |
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